Histopathologic, immunophenotypic and genotypic analyses in ocular adnexal lymphoproliferative disorders
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چکیده
منابع مشابه
Clinical Aspects of IgG4-Related Orbital Inflammation in a Case Series of Ocular Adnexal Lymphoproliferative Disorders
The most frequent ocular adnexal tumors and simulating lesions are lymphoproliferative disorders (LPDs), including malignant lymphomas and orbital inflammation with lymphoid hyperplasia or infiltration. IgG4-related orbital inflammation (IgG4-ROI) often involves lacrimal glands and other orbital tissues and is an important differential diagnosis. The present study evaluated clinical aspects of ...
متن کاملGenome-Wide Analysis of Ocular Adnexal Lymphoproliferative Disorders Using High-Resolution Single Nucleotide Polymorphism Array.
PURPOSE We identified the genomic signature of ocular adnexal lymphoproliferative disorders (LPDs), especially ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma, IgG4-related ophthalmic disease (IgG4-ROD), reactive lymphoid hyperplasia (RLH), and diffuse large B-cell lymphoma (DLBCL). METHODS We included 52 subjects with ocular adnexal LPDs (13 orbital MALT lymphomas, 16 conjun...
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The value of DNA hybridisation (using immunoglobulin and T cell receptor gene probes) was assessed during the diagnosis of problematical lymphoid tissue biopsy specimens. In 14 of 18 specimens (78%), which contained a malignant lymphoproliferation of uncertain aetiology, this technique permitted the demonstration of a monoclonal proliferation of B cells (nine cases) or T cells (five cases). In ...
متن کامل2251 Ocular adnexal lymphoproliferative disease. The role of immunohistochemistry and gene analysis in diagnosis
Purpose: Lympboprolifcrativc ocular adnexal lesions represent 1 spectrum of disorders which range from reactive lymphoid hyperplasia to malignant lymphoma and include lewas which ared an mddcrminatc nature morphologrccally and immunophenotypically. Futhmnwe cases have been ckcvmented where progresswn from reactix hyperplasia to frank Ippboma has camed. We have applied molecular genetIc te&lques...
متن کاملA Clinicopathologic Study of Orbital and Ocular Adnexal Lymphoproliferative Lesions with Immunohistochemical Staining of Indeterminate Cases
The histopathologic diagnosis of orbital and ocular adnexal lymphoproliferative lesions is difficult, resulting contraversy in classification, determining benignity or malignancy of them and treatment modality selection. We designed the following study to evaluate clinical, histopathologic and if necessary immunochemical features of them in decreasing indeterminate cases. The study includes 51 ...
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ژورنال
عنوان ژورنال: Australian and New Zealand Journal of Ophthalmology
سال: 1992
ISSN: 0814-9763,1440-1606
DOI: 10.1111/j.1442-9071.1992.tb00948.x